KMID : 1130320100530040585
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Korean Journal of Pediatrics 2010 Volume.53 No. 4 p.585 ~ p.591
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The natural history and prognostic factors of Graves¡¯ disease in Korean children and adolescents
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Song Seung-Min
Yoon Ji-Seok Ko Jung-Min Cheon Chong-Kun Choi Jin-Ho Yoo Han-Wook
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Abstract
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Purpose: Graves¡¯ disease is the most common cause of hyperthyroidism in children and adolescents. In this study, we investigated the natural course and the prognostic factors of Graves¡¯ disease in Korean children and adolescents.
Methods: One-hundred thirteen (88 girls and 25 boys) patients were included in this study. A retrospective analysis was made of all patients who were diagnosed with Graves¡¯ disease. The following parameters were recorded and analyzed: patient¡¯s sex, age at diagnosis, duration of disease, laboratory findings, symptoms and signs, and family history of autoimmune thyroid disease.
Results: All patients were initially treated with antithyroid drugs, either methimazole (93.8%) or propylthiouracil (6.2%). Antithyroid drugs had been discontinued in 75 (66.4%) of 113 patients. Of these 75 patients, 23 (20.4%) relapsed after 25.5¡¾33.7 months. Thirteen (11.5%) of 23 patients, who experienced the first relapse, showed a second remission. However, 2 (1.8%) of 13 patients relapsed again. Euthyroid state could not be achieved by antithyroid drugs in 1 patient, and radioactive iodine therapy was performed. The older the patient at diagnosis, the greater the likelihood of remission (P =0.034).
Conclusion: Age at diagnosis seems to be a prognostic factor in Korean children and adolescents with Graves¡¯ disease, and should be taken into account in treatment plan determination.
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KEYWORD
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Graves¡¯ disease, Natural course, Prognostic factor
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